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NATCHITOCHES, La. - Multiple law enforcement agencies responded to a major two-vehicle crash involving multiple injuries on I-49 around 7:40 p.m. Tuesday night. According to the Natchitoches Sheriff's office, the crash occurred near milepost #149 north of Powhatan. Traffic was condensed to one lane near the crash. The sheriff's office said the Natchitoches Parish Coroner's Office also responded to the scene. No word yet on the identities of those involved.