Texas DPS troopers responded to a wreck on Thursday afternoon.
It was a two-vehicle fatal crash on Hwy 64 W and CR 1154 in Smith County, according to DPS.
According to a preliminary report by DPS, a 1995 Toyota Tacoma driven by Alexander N. Woods, 31, of Tyler was traveling west on Hwy 64.
A white 2011 Chevrolet Silverado was traveling east on Hwy 64, driven by Becky E. Browning, 57, or Irving. Her passenger was Wayne D. Whitworth, 56, of Ben Wheeler.
DPS says that for an unknown reason the Tacoma crossed into oncoming traffic, and struck the Silverado head on.
Woods died at the scene.
Browning and Whitworth are in a Tyler hospital in serious condition.